City of Hope Orange County is transforming cancer treatment by bringing world-class expertise and specialized care closer to home. Supported by a regional network of care, our 11-acre academic cancer campus in Irvine is home to City of Hope Orange County Lennar Foundation Cancer Center, our outpatient cancer center, and Orange County’s only cancer specialty hospital, opening in late 2025.

With the opening of the hospital, the full continuum of advanced cancer care—from prevention through survivorship—will be available in Orange County for the first time, eliminating the need to travel for lifesaving treatment. Seamlessly connected to our outpatient cancer center, the new clinical research hospital will feature 73 inpatient beds, advanced surgical suites, groundbreaking clinical trials, and holistic services such as rehabilitative therapy and spiritual care. This isn’t standard cancer care. This is lifesaving cancer care. This is Hope.

Are you an experienced ICU nurse looking for an opportunity to make a real difference in the lives of cancer patients?  Join our team at City of Hope Orange County Cancer Specialty Hospital as a Clinical Nurse III in the ICU and be part of a groundbreaking team dedicated to providing world-class, compassionate care to critically ill oncology patients.

As a Clinical Nurse III, you will play a vital role in guiding and coordinating care for patients in the ICU, ensuring the highest standards of treatment in accordance with our Nursing Department’s policies and procedures.  From comprehensive patient assessments and personalized care planning to implementing treatment plans and collaborating with interdisciplinary teams, your expertise will directly impact patient outcomes. Our ICU unit will have 8 beds and flex of Medical Surgical patients. 

We are looking for passionate, skilled nurses who can think critically, act decisively, and provide compassionate support to patients and families.  Your ability to effectively communicate, document, and integrate cultural, psychosocial, and spiritual needs into care plans will be key to delivering exceptional care.

As a successful candidate, you will: 

• Utilizes the nursing process and practice standards as a framework for the management of patient care.
• Demonstrates the ability to utilize effective critical thinking skills.
• Analyzes the assessment data to determine a nursing diagnosis and appropriate interventions.
• Delegates to licensed and unlicensed personnel.
• Demonstrates knowledge of the clinical information system and applies principles to patient documentation.
• Demonstrates the ability to integrate knowledge of job specific competencies.  Identifies, develops, and implements an action plan for self-development and professional growth that also includes peer review.
• Serves as a mentor and role model to new staff members.
• Integrates and practices according to the City of Hope Professional Practice Model to deliver care service excellence.  
• In alignment with City of Hope mission and values, the Division of Nursing and Patient Care Services vision and mission, and with continuous focus on the patient, family and community, carries out the nursing process, coordinates interdisciplinary care planning, documents according to standards, including validation of the patient and caregiver’s understanding of the plan of care and expected outcomes.
• The nurse is a change agent, committed to lifelong learning, professional development and embodiment of City of Hope organizational mission and values, and the values and ethos of the profession of nursing.
• Sign On Bonus: $20,000
• Shift: Nights
• This position is also eligible for a night shift differentials up to $6.50/hr and weekend differential up to $15.60/hr.   
• Multiple Positions Available

Your qualifications should include: 

• Bachelor’s degree or master's degree in nursing 
• 3 -5 years related experience
• Current CA Registered Nurse License
• Current Basic Life Support (BLS) through American Heart Association
• Current Advanced Cardiac Life Support (ACLS) through American Heart Association

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.  To learn more about our commitment to diversity, equity, and inclusion, please click here.

To learn more about our Comprehensive Benefits, please CLICK HERE.